Liver disease or disorders can result from a wide variety of causes, including infections, drugs, toxins, ischemia and autoimmune disorders. Most liver disorders produce degree of hepatocellular injury and necrosis, resulting in various abnormal laboratory test results and sometimes, symptoms.
Classes and symptoms of Liver Disease:
- Acute Viral Hepatitis is due to specific viruses that have diverse modes of transmission and epidemiologies. This is characterized by alterations in olfaction and taste, anorexia, arthralgias, coryza, cough, fatigue, low-grade fever, headache, malaise, myalgias, nausea and vomiting, liver becomes enlarged and tender, right upper quadrant pain and discomfort, splenomegaly, cervical adenopathy.
The following are types of acute viral hepatitis:
- Hepatitis A Virus (HAV) spreads primarily by fecal-oral contact and thus may occur in areas of poor hygiene
- Hepatitis B Virus (HBV) are often transmitted parenterally, typically through contaminated blood or blood products
- Hepatitis C Virus (HCV) are commonly transmitted through blood, primarily when parenteral drug users share needles, also through tattoos or body piercing
- Alcoholic Hepatitis occurs with alcohol consumption which exceeds 80 g/day. It is characterized by fatigue, fever, jaundice, right upper quadrant pain, tender abdomen due to enlarged liver and sometimes a hepatic bruit.
- Drug Induced Liver Damage is characterized by Jaundice (a yellowish pigmentation of the skin and the conjunctival membranes)
- Fatty Liver (steatosis) - excessive accumulation of lipid hepatocytes. It is characterized by fatigue, malaise or right upper quadrant abdominal discomfort.
- Liver Cirrhosis is characterized by weakness, anorexia, malaise, and weight loss, loss of appetite, nausea and vomiting, enlargement of the liver, jaundice, itching, ascites, vomiting of blood, increased sensitivity to drugs and encephalopathy (impending coma)
Commonly Prescribed Drugs