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Drug Interaction Checker

Drug interactions occur when the effect of a certain drug is altered or changed when it is taken with another drug, chemical, or food. The effect may be increased or decreased, or the result may be either desirable or undesirable. Some drug interactions can cause harmful side effects.

Learn more about what drug interacts with other drugs by entering the brand, generic, or drug classification in the search box below.

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DISCLAIMER : Every effort has been made to ensure that the drug interaction information above is accurate and updated. However, no guarantee can be made to that effect, since drug information may be time-sensitive, and discoveries in the health sciences may shed light on new relevant information. The drug interaction information only serves to supplement the knowledge, skill, and judgment of doctors and other healthcare practitioners, not replace them. It should not be relied upon solely for final treatment decisions. The publisher and editor are not liable for any injury and/or damage to persons and property arising from misuse or reliance upon, in any way, the information contained in the drug interaction chart.

PREDISPOSING FACTORS FOR DRUG INTERACTIONS

Patient-related factors

Age
Incidence of adverse drug reaction appears to be highest in the very young and very old people. In these two extreme periods of life, there is poorly developed and altered physiological function respectively. Therefore, metabolism and elimination of some drugs may be delayed.

Sex
Studies have shown that for some drugs women are more likely to suffer from ADRs than men.

Pathophysiological conditions
Diseases (diabetes, asthma, hypertension, etc.) can alter drug absorption, metabolism, elimination, and the body’s response to drugs.

Previous history of allergy
Patients who have previously suffered an allergic drug reaction appear to be more susceptible than others to allergic ADRs in general.

Genetics

Lifestyle
Alcoholism, smoking may lead to the occurrence of interactions.

Multiple Drug Therapy (Polypharmacy)
Incidence of ADRs increases with the number of drugs given due to risk of interactions.

Multiple prescribers

Prevention

· Review drug history and patient risk factors.
· Avoid complex or multiple drug therapy and multiple prescribers.
· Lifestyle modification.

Management

· Suggest a different drug for significant drug interaction.
· Instruct patient as to adhere on the rational drug therapy.
· Monitor the patient for response to medication and note occurrence of unexpected reactions that may occur.

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